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Studies suggest that CBD can reduce inflammation-induced inducible NOS (iNOS) expression while maintaining or enhancing endothelial NOS (eNOS)-mediated NO production, leading to decreased oxidative stress, improved endothelial function, and reduced neuroinflammation

While the results of this clinical study have been submitted for publication, they are not yet publicly available

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One-electron oxidation of AA is also possible, generating a semi-dehydro-ascorbyl radical (Kocot et al., 2017)

The subsequent release of free fatty acids (FFAs) into circulation impairs insulin signaling across multiple peripheral tissues ( Table 2 Integrated analysis of adipocyte dysfunction: from molecular mechanisms to systemic impact